T2R: A G Protein-coupled Receptor for Bitter Tastes (P37804)

Target Name: Taste receptor type 2

NCBI ID: P37804

Taste receptor type 2

Other Name(s): Bitter taste receptor | TAS2R | T2R

T2R: A G Protein-coupled Receptor for Bitter Tastes

Taste receptor type 2 (T2R) is a G protein-coupled receptor that is expressed in the taste buds of the tongue and is responsible for mediating the sensation of bitterness. T2R is one of the five taste receptors, along with T1R (sweet), T2R (bitter), T3R (umami), and T4R (tart), that are known to play a crucial role in human taste perception.

T2R is a nonspecific subtype of taste receptor type 2, which means that it is one of the subtypes of T2R that are found in the taste buds. There are two main types of T2R, which are T2Ra and T2Rb. T2Ra is the most abundant T2R subtype, while T2Rb is less common.

T2R is expressed in the taste buds and is involved in the sensation of bitterness. When T2R is stimulated, it sends a signal to the brain via the nervous system to indicate that the taste is bitter. This sensation of bitterness can be described as a bitter or unpleasant taste.

One of the things that makes T2R an attractive drug target is its unique function in taste perception. T2R is the only taste receptor that is responsible for mediating the sensation of bitterness, which means that it has the potential to be used to treat conditions that are characterized by bitter tastes, such as taste disorders or dental problems.

Another reason for the potential of T2R as a drug target is its location in the taste buds. The taste buds are the small structures that are found in the tip of the tongue and are responsible for transmitting taste information to the brain. By targeting T2R, drugs could potentially be used to treat conditions that are related to the function of the taste buds, such as dental problems or taste disorders.

T2R is also an interesting biomarker for certain diseases. For example, individuals with taste disorders may have an imbalance in the levels of T2R in their taste buds, which could be used as a diagnostic marker for these conditions. Additionally, T2R levels have been used as a biomarker for certain diseases, such as cancer, as a potential target for cancer therapies.

In conclusion, T2R is a taste receptor that is involved in the sensation of bitterness and has the potential to be used as a drug target or biomarker. With further research, it is possible that T2R will be used to treat a variety of conditions that are characterized by bitter tastes or related to the function of the taste buds.

Protein Name: Taste Receptor Type 2 (nonspecified Subtype)

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